This nationwide Response Plan is intended to contribute to tackling the enormous Sexual and Reproductive Health (SRH) and Gender-Based Violence (GBV) needs as a consequence of multiple shocks, including the influx of refugees and returnees to Ethiopia as a result of the recent conflict in Sudan. The plan provides a brief analysis of core humanitarian issues at the national and regional levels, defining the SRH and GBV needs in humanitarian settings, and finally proposes UNFPA strategies to tackle the needs with corresponding funding needs.